Y.R. Han and P.I. Lee. Effect of extent of supersaturation on the evolution of kinetic solubility profiles. Mol. Pharmaceutics, 14, 206-220 (2017).

 

C.B.M. Figueirêdo, D. Nadvorny, A.C.Q. de Medeiros-Vieira, J.L. Soares-Sobrinho, P.J. Rolim-Neto, P.I. Lee and M.F. de La Roca-Soares, Enhancement of dissolution rate through eutectic mixture and solid solution of posaconazole and benznidazoleInt. J. Pharm., 525, 32-42 (2017).

 

J. Brady, T. Durig, P.I. Lee and J.-X. Li. Polymer Properties and Characterization. In: Y. Qiu, Y. Chen, G. Zhang, L. Yu and R.V. Mantri (Eds.), Developing Solid Oral Dosage Forms, 2nd Ed., Academic Press, Cambridge, MA, 2017, pp. 181-224.

 

Y. Qiu and P.I. Lee. Rational Design of Oral Modified-Release Drug Delivery Systems.  In Y. Qiu, Y. Chen, G. Zhang, L. Yu and R.V. Mantri (Eds.), Developing Solid Oral Dosage Forms, 2nd Ed., Academic Press, Cambridge, MA, 2017, pp. 519-554.

 

Z. Li and P.I.Lee. Investigtion on drug solubility enhancement using deep eutectic solvents and their derivatives. Int. J. Pharm., 505, 283-288 (2016).

 

D.D. Sun and P.I. Lee. Haste makes waste: The interplay between dissolution and precipitation of supersaturating formulations. AAPS J., 17: 1317-1326 (2015).

 

D.D. Sun and P.I. Lee. Probing the mechanisms of drug release from amorphous solid dispersions in medium-soluble and medium-insoluble carriers. J. Control. Release, 211: 85-93 (2015).

 

D.D. Sun and P.I. Lee. Evolution of supersaturation of amorphous pharmaceuticals: Nonlinear rate of supersaturation generation regulated by matrix diffusion, Mol. Pharmaceutics, 12: 1203-1215 (2015).

 

D.D, Sun and P.I. Lee. Cover story, Acta Pharm. Sinica B, 4: 2 (2014).

 

D.D. Sun and P.I. Lee. Crosslinked hydrogels - a promising class of insoluble solid molecular dispesion carriers for enhancing the delivery of poorly soluble drugs, Acta Pharm. Sinica B, 4: 26-36 (2014).

 

D.D. Sun and P.I. Lee. Evolution of supersaturation of amorphous pharmaceuticals: The effect of rate of supersaturation generation, Mol. Pharmaceutics, 10: 4330-4336 (2013).

 

B. Qu and P.I. Lee. A rotating disk electrokinetic method for characterizing polyelectrolyte pharmaceutical gels, Eur. J. Pharm. Biopharm., 81: 199-206 (2012).

 

D.D. Sun, T.R. Ju and P.I. Lee. Enhanced kinetic solubility profiles of indomethacin amorphous solid dispersions in poly(2-hydroxyethyl methacrylate) hydrogels, Eur. J. Pharm. Biopharm., 81: 149-158 (2012).

 

P.I. Lee. Modeling of drug release from matrix systems involving moving boundaries: Approximate analytical solutions, Int. J. Pharm., 418: 18-27 (2011).

 

P.I. Lee and J.-X. Li. Evolution of Oral Controlled Release Dosage Forms. In: H. Wen and K. Park (Eds.), Oral Controlled Release Formulation Design and Drug Delivery: Theory to Practice, John Wiley & Sons, Hoboken, NJ , 2010, pp. 21-31.

 

Y. Li and P.I. Lee. Controlled nitric oxide delivery platform based on S-nitrosothiol conjugated interpolymer complexes for diabetic wound healing, Molecular Pharmaceutics, 7: 254-266 (2010).

 

Y. Li and P.I. Lee. A new bioerodible system for sustained local drug delivery based on hydrolytically activated in situ macromolecular association, Int. J. Pharm., 383: 45-52 (2010)

 

S. Sotthivirat, J.L. Haslam, P.I. Lee, V.M. Rao, and V.J. Stella. Release mechanisms of a sparingly water-soluble drug from controlled porosity-osmotic pump pellets using sulfobutylether-b-cyclodextrin as both a solubilizing and osmotic agent, J. Pharm. Sci., 98: 1992-2000 (2009).

 

S.A. Sangekar, P.I. Lee and A.A. Nomeir. Molecular Dispersion Composition with Enhanced Bioavailability, Canadian Patent No. 2,315,685, February 5, 2008.

 

P. Zahedi and P.I. Lee. Solid molecular dispersions of poorly water-soluble drugs in poly(2-hydroxyethyl methacrylate) hydrogels. Eur. J. Pharm. Biophram., 65: 320-328 (2007).

 

A.M. Bello, E. Poduch, M. Fujihashi, M. Amani, Y. Li, I. Crandall, R. Hui, P.I. Lee, K.C. Kain, E.F. Pai and L.P. Kotra. A potent, covalent inhibitor of orotidine 5'-monophosphate decarboxylase with antimalarial activity, J. Med. Chem., 50: 915-921 (2007).

 

S.A. Sangekar, W.A. Vadino and P.I. Lee. Oral Composition Comprising a Triazole Antifungal Compound, Canadian Patent No. 2,258,683, July 31, 2007.

 

S.A. Sangekar, W.A. Vadino and P.I. Lee. Solid Solution of an Antifungal Agent with Enhanced Bioavailability, Canadian Patent No. 2,258,679, May 29, 2007.

 

J.-X. Li, P.I. Lee. Effect of sample size on Case II diffusion of methanol in poly(methyl methacrylate) beads. Polymer, 47: 7726-7730 (2006).

 

P.I. Lee, Comments on "Modelling the controlled release of drug embedded in a plate-like polymer matrix" by Lin et al. Chem. Eng. Sci., 60: 7172-7173 (2005).

 

S.A. Sangekar, P.I. Lee and A.A. Nomeir. Molecular Dispersion Composition with Enhanced Bioavailability, US Patent No. 6,632,455, October 14, 2003.

 

T. Jin, P. Pennefather and P.I. Lee. Lipid Vesicle System, US Patent No. 6,284,375, September 4, 2001.

 

X.Y. Wu and P.I. Lee. Preparation and characterization of inulin ester microspheres as drug carriers. J. Appl. Polym. Sci., 77 (4): 833-840 (2000).

 

G.L. Amidon, P.I. Lee and E.M. Topp, eds. Transport Processes in Pharmaceutical Systems, Marcel Dekker, N.Y., 1999.

 

S.A. Sangekar, P.I. Lee and W.A. Vadino. Solid Solution of an Antifungal Agent with Enhanced Bioavailability, US Patent No. 5,972,381, October 26, 1999.

 

S.A. Sangekar, W.A. Vadino and P.I. Lee. Oral Antifungal Composition, US Patent No. 5,846,971, December 8, 1998.

 

S.A. Sangekar, W.A. Vadino and P.I. Lee. Antifungal Composition with Enhanced Bioactivity, US Patent No. 5,834,472, November 10, 1998.

 

P.I. Lee . Oral ER technology: Mechanism of release. In: G.L. Amidon, J.R. Robinson and R.L. Williams (Eds.), Scientific Foundations For Regulating Drug Product Quality, AAPS, Alexandria, VA, 1997, pp. 222-231.

 

T. Jin, P. Pennefather and P.I. Lee. Lipobeads: A hydrogel anchored lipid vesicle system. FEBS Letters, 397: 70-74 (1996).

 

C.J. Kim and P.I. Lee. Enhanced and retarded drug release from hydrophobic ionic beads. J. Macormol. Sci.-Pure Appl. Chem., A33 (9):1227-1238 (1996).

 

K.A. Gates, H. Grad, P. Birek and P.I. Lee. A new bioerodible polymer insert for the controlled release of metronidazole. Pharmaceutical Research, 11 (11): 1607-1611 (1994).

 

A.T. Pham and P.I. Lee. Probing the mechanisms of drug release from hydroxypropylmethyl cellulose matrices. Pharmaceutical Research, 11 (10): 1379-1384 (1994).

 

X.Y. Wu and P.I Lee. Preparation and characterization of thermal and pH-sensitive nanospheres. Pharmaceutical Research, 10 (10): 1544-1547 (1993)

 

X. Xu and P.I. Lee. Programmable drug delivery from an erodible association polymer system. Pharmaceutical Research, 10 (8): 1144-1152 (1993).

 

P.I.Lee. Swelling and dissolution kinetics during peptide release from erodible anionic gel beads. Pharmaceutical Research, 10 (7): 980-985 (1993).

 

P.I. Lee. Constant-rate drug release from novel anionic gel beads with transient composite structure. J. Pharm. Sci., 82 (9), 964-968 (1993).

 

P.I. Lee. Poly(vinyl alcohol) membrane systems for the controlled release of chlorinated isocyanurates. J. Appl. Polym. Sci., 50: 941-947 (1993).

 

P.I. Lee. Temperature dependence of methanol transport in spherical PMMA beads. Polymer, 34: 2397-2400 (1993).

 

C.-J. Kim and P.I. Lee. Effect of loading on swelling-controlled drug release from hydrophobic polyelectrolyte gel beads. Pharmaceutical Research, 9 (10), 1268-1274 (1992).

 

S.M. Dinh, B. Berner, Y.-M. Sun, and P.I. Lee. Sorption and transport of ethanol and water in poly(ethylene-co-vinyl acetate) membranes. J. Membrane Science, 69: 223-234 (1992).

 

C.-J. Kim and P.I. Lee. Synthesis and characterization of suspension-polymerized poly(vinyl alcohol) beads with core-shell structure. J. Appl. Polym. Sci., 46: 2147-2157 (1992).

 

M.V. St-Pierre, P.I. Lee, and S. Pang. A comparative investigation of hepatic clearance models: predictions of metabolite formation and elimination. J. Pharmacokin. Biopharm., 20 (2): 105-145 (1992)

 

P.I. Lee. Diffusion-controlled matrix systems In: A. Kydonieus (Ed.),Treatise On Controlled Drug Delivery: Physicochemical Basis, Optimization, Applications, Marcel Dekker, New York, N.Y.,1992, pp.155-197.

 

P.I. Lee and S.K. Lum. Swelling-induced zero-order release from rubbery polydimethylsiloxane beads. J. Controlled Release, 18: 19-24 (1992).

 

P.I. Lee and C.-J. Kim. Effect of geometry on swelling front penetration in glassy polymers. J. Membrane Science, 65: 77-92 (1992).

 

C.-J. Kim and P.I. Lee. Hydrophobic anionic gel beads for swelling-controlled drug delivery. Pharmaceutical Research, 9 (2): 195-199 (1992).

 

C.-J. Kim and P.I. Lee. Composite poly(vinyl alcohol) beads for controlled drug delivery. Pharmaceutical Research, 9 (1): 10-16 (1992).

 

P.I. Lee. Swelling effect of semicrystalline poly(vinyl alcohol) in hydrogen peroxide. J. Appl. Polym. Sci., 42 (12): 3077-3082 (1991).

 

P.I. Lee and C.-J. Kim. Probing the mechanisms of drug release from hydrogels. J. Controlled Release, 16: 229-236 (1991).

 

C.-J. Kim and P.I. Lee, Suspension polymerized poly(vinyl alcohol) beads for drug delivery. Polym. Mater. Sci. Eng., 63: 64-67 (1990).

 

S.H. Gehrke and P.I. Lee. Hydrogels for drug delivery dystems. In: P. Tyle (Ed.), Specialized Drug Delivery Systems: Manufacturing and Production Technology, Marcel Dekker, New York, N.Y., 1990, pp. 333-392.

 

J.H. Kou, G.L. Amidon and P.I. Lee. pH-Dependent swelling and solute diffusion characteristics of poly-(hydroxyethyl methacrylate-co-methacrylic acid) hydrogels. Pharmaceutical Research, 5: 592-597 (1988).

 

P.I. Lee. Synthetic hydrogels for drug delivery: preparation, characterization, and release kinetics. In: D. Hsieh (ed.), Controlled Release Systems: Fabrication Technology, Vol.2, CRC Press, Boca Raton, Florida, 1988, pp. 61-82.

 

P.I. Lee and N.A. Peppas. Prediction of polymer dissolution in swellable controlled release systems. J. Controlled Release, 6: 207-215 (1987).

 

P.I. Lee and W.R. Good, eds. Controlled Release Technology: Pharmaceutical Applications, ACS SYMPOSIUM SERIES NO. 348, American Chemical Society, Washington, D.C., 1987.

 

E.E. Parsonage, N.A. Peppas and P.I. Lee. Properties of positive resists. II. Dissolution characteristics of irradiated poly(methyl methacrylate) and poly(methyl methacrylate-co-maleic anhydride). J. Vac. Sci. Tech., Part B, 5: 538-545 (1987).

 

P.I. Lee. Initial concentration distribution as a mechanism for regulating drug release from diffusion controlled and surface erosion controlled matrix systems. J. Controlled Release, 4: 1-7 (1986).

 

P.I. Lee. Kinetics of drug release from hydrogel matrices. J. Controlled Release, 2: 277-288 (1985).

 

P.I. Lee. Effect of non-uniform initial drug concentration distribution on the kinetics of drug release from glassy hydrogel matrix. Polymer, 25: 973-978 (1984).

 

P.I. Lee. A novel approach to zero-order drug delivery via immobolized non-uniform drug distribution in glassy hydrogels. J. Pharm. Sci., 73:(10), 1344-1347 (1984).

 

W.R. Good and P.I. Lee. Membrane reservoir controlled drug delivery systems. In: R.S. Langer and D.L. Wise (eds.), Medical Applications of Sustained Release, Vol. 1, CRC Press, Boca Raton, Florida, 1984, pp. 1-39.

 

P.I. Lee. Dimensional changes during drug release from a glassy hydrogel matrix. Polymer, 24:(Communications), 45-47 (1983).

 

P.I. Lee. Controlled drug release from polymeric matrices involving moving boundaries. In: D. Lewis, ed., Controlled Release of Pesticides and Pharmaceuticals, Plenum Publishing, New York, New York, 1981, pp. 39-48.

 

P.I. Lee. Diffusional release of a solute from a polymeric matrix - Approximate analytical solutions. J. Membrane Science, 7: 255-275 (1980).

 

P.I. Lee. Determination of diffusion coefficients by sorption from a constant, finite volume. In: R.W. Baker, ed., Controlled Release of Bioactive Materials, Academic Press, New York, NY, 1980, pp. 135-153.

 

 PIL Research Group 2014. Designed by Zheng Li.

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