Professor Ping Lee and PhD graduate Dajun Sun recently published a paper, “Probing the mechanisms of drug release from amorphous solid dispersions in medium-soluble and medium-insoluble carriers,” that was featured on the cover of the Journal of Controlled Release.
Using a simple but clever experimental design to control polymer solubility and drug release mechanisms, this study differentiates the dissolution and supersaturation behaviours of amorphous solid dispersions in medium-soluble and medium-insoluble polymer carriers by altering their pH. In so doing, Professor Lee and Dr. Sun show that the supersaturation profile of the medium-insoluble carriers are distinctively different than those based on conventional medium-soluble carriers, as they lack the initiation surge of supersaturation and provide extended sustained release properties without the use of crystallization inhibitors.
In the commentary that accompanies this study, Journal of Controlled Release editor-in-chief Professor Kinam Park notes how this is “an important discovery” by the Lee group that “mechanistic insights gained here should open new avenues for improving the in vivo supersaturation behaviors of poorly water-soluble drugs through selecting appropriate medium-soluble and/or medium-insoluble ASD carriers.”
(News & Announcements, July 13, 2015; http://pharmacy.utoronto.ca/newsfeed/lee-jcr-07-15)
Professor Ping Lee at the Leslie Dan Faculty of Pharmacy is the recent recipient of a 5-year Natural Sciences Engineering Research Council of Canada (NSERC) Discovery Grant to explore the evolution of supersaturation generation from solid solutions of poorly soluble drugs based on glassy hydrogels.
(News & Announcements, Jun 27, 2014; www.pharmacy.utoronto.ca/newsfeed/lee-evolution-supersaturation-06-2014)
“Accolades for Professor Ping Lee”- Professor Ping I. Lee, GlaxoSmithKline Chair in Pharmaceutics and Drug Delivery has recently been recognized for his many achievements in the field of pharmaceutical sciences. At the American Association of Pharmaceutical Scientists’ Annual Meeting and Exposition in San Antonio, Texas this month, Dr. Lee was conferred the title of Fellow for his sustained remarkable scholarly and research contributions to the pharmaceutical sciences. The American Association of Pharmaceutical Scientists bestows the honour of Fellow to individuals who elevate the stature of the pharmaceutical sciences, demonstrate superior professional excellence, and have made exceptional contributions within their specific fields. Dr. Lee’s accomplishments are also referenced in the journal article “Historical perspective on advanced drug delivery. How engineering design and mathematical modeling helped the field mature” in Advanced Drug Delivery Review 65 (2013)
(News & Announcements, Nov 21, 2013; www.pharmacy.utoronto.ca/about-us/news-and-announcements?page=4)
Professor Ping Lee has been awarded a Connaught Innovation Award for his work in developing a novel extended release nitric oxide delivery technology to treat ophthalmic diseases. The Connaught Innovation Award provides Dr. Lee with the opportunity to generate proof-of-principle data demonstrating the safety, tolerability and enhanced ocular retention of ophthalmic formulations of his NO releasing polymer system in an animal model.
(Pharmacopoeia April 15, 2013)
Boundless Campaign brochure
“University of Toronto grants exclusive rights to Wound Healing Technology to Cardium Therapeutics”- Dr. Ping Lee, a Professor at the University of Toronto’s Leslie Dan Faculty of Pharmacy and GlaxoSmithKline Chair in Pharmaceutics and Drug Delivery and his team have created a new sustained-release form of nitric oxide (NO) that can not only stop the infections at the wound sites, but also has the potential to speed up wound-healing… Cardium Therapeutics Inc. (Amex: CXM) of San Diego [www.cardiumthx.com] acquired the rights to use this Canadian discovery to expand its wound-healing portfolio, which includes dressings, topical creams and gels, and electrospun fibers for bandages.
(Cardium-UofT-Mars Innovation Press Release, October 14, 2010)
Dr. Ping Lee, the GlaxoSmithKline Chair in Pharmaceutics and Drug Delivery, was recently quoted in a number of online stories, including Market Watch and The Medical News. In 2009, Dr. Lee aligned with MaRS Innovation to commercialize the novel nitric oxide sustained release technology developed in his laboratory. Cardium Therapuetics has now gained exclusive access to commercial development rights for this wound healing and tissue regeneration technology.
(Pharmacopoeia October 13, 2010)
The MaRS Innovation commercialization enterprise of Professor and GlaxoSmithKline Chair in Drug Delivery Ping Lee’s discovery was noted in Pharmafocus. Dr. Lee's development of a sustained release formulation of nitric oxide (NO) for applications in wound healing is only the second discovery licensed for commercial development by MaRS Innovation.
(Pharmacopoeia August 31, 2009)
Research Notes: In June, MaRS Innovation and the University of Toronto announced an agreement to commercialize a novel sustained release formulation of nitric oxide (NO) for applications in wound healing, including diabetic ulcers. The disruptive technology that facilitates the therapeutic release of NO over a two-week period has been developed by Professor and GlaxoSmithKline Chair in Pharmaceutics and Drug Delivery, Ping Lee.
(Endeavour, Vol 3, Issue 1, University of Toronto)
Faculty News: Professor Ping Lee has been reappointed for a five-year term as the GlaxoSmithKline Chair in Pharmaceutics and Drug Delivery. Dr. Ping Lee's reappointment will allow him to continue his research on the formation, characterization, and drug delivery applications of nanostructured drug-polymer composites.
(Pharmacopoeia May 7, 2009)
GlaxoSmithKline Chair in Pharmaceutics and Drug Delivery Ping Lee was profiled in the February 24th issue of The Bulletin. The article was a centre spread on drugs that focused on how research conducted at U of T is helping deliver better medicines more effectively and alleviate pain.
(Pharmacopoeia Feb 27 2009 )
“Polymers may aid drug absorption”- Getting the right drug at the right time is key for almost any patient but making sure the drug is actually being absorbed properly by the body is even more important. Pharmacy Professor Ping Lee and his team are looking at ways to “get that medicine down” and improve how the body absorbs several poorly soluble drugs.
(University of Toronto Bulletin, February 24, 2009)
PIL Research Group 2014. Designed by Zheng Li.