Our research program focuses on studying the molecular mechanism of signal transduction machineries.

Our interests are divided into three main themes:

1) The study of the signalling pathways activated by the Wnt and Hedgehog families of secreted glycoproteins.

2) The study of cell signalling activated by G Protein Coupled Receptors and Heterotrimeric G Proteins.

3) The molecular mechanisms underlying the functions of Cullin-RING E3 ubiquitin ligases.

We use a combination of biochemical and molecular biology approaches with new tools in proteomics and mass spectrometry to assess the function of specific proteins within protein complexes.